Effective treatment of diseases and disorders relies on rapid diagnosis. Most commonly, the tests required for this diagnosis require trained personnel, expensive equipment, and travel (i.e., visiting a hospital or clinic). Unfortunately, this type of travel and/or the lack of economic means prohibits many from beginning this diagnostic process. Beyond diagnostics, constant monitoring of key biomarkers—or prescription medication levels—during treatment is also important to ensure adequate care is being received. Standard benchtop electrochemical workstations are large, expensive and not suitable for use outside of well-equipped laboratories employing trained personnel. For these reasons, the development of simple to use devices – and the access to portable electrochemical readers – which can be used at the point-of-care for the determination of key analytes will be an important contribution to reliable patient care and early diagnosis. Toward this goal, my research program will develop new, simple to use, POC devices for the detection of clinically relevant biomarkers using low-cost materials (i.e., paper, thread, pins, etc.).