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College of Arts and Sciences Department of Chemistry

Department of Chemistry Seminar – Dr. Ping Yang

Chemistry Department Seminar

 Monday, November 9th @ 4:10 pm – 5:00 pm |  ZOOM Only

Dr. Ping Yang,  Los Alamos National Laboratory, New Mexico, 87545, United States

Host: Dr. Aurora Clark

Title: Structure, Stability, and Chemistry of Actinide Nanocrystals – Insights from Quantum Simulations

Abstract: Nanoscale materials bearing heavy elements have a wide range of applications from the nuclear fuel cycle to environment and health. Nanocrystals (NCs) with size and shape dependent properties are a thriving research field and remarkable progress has been made in the controlled synthesis and characterization of NCs composed of stable elements in the past three decades. In this context, interfacial chemistry of nano-sized materials is critical for controlling the morphology that drives their unique associated chemical and physical properties. The understanding of NCs containing f-elements is comparatively limited due to difficulties in handling them both experimentally and theoretically.  In this talk, I will share some recent progress in understanding the interplay between surface energy, surfactant ligands, and the chemistry in determining the morphology of 5f-element nanoparticles. I will show how quantum simulations can provide a molecular-level picture of the relevant driving forces and dynamic properties.

[1]     G Wang, ER Batista, P Yang. Phys Chem Chem Phys 2018, 20, 17563

[2]     G Wang, ER Batista, P Yang, J. Phys Chem C, 2019, 123, 30245

[3]     RK Carlson, MJ Cawkwell, ER Batista, P Yang, J. Chem. Thoery Compt 2020, 16, 3073

[4]     NF Aguirre, J Jung, P Yang, Phys Chem Chem Phys 2020, 22, 18614

[5]     G Wang, ER Batista, P Yang, Appl Sci 2020, 10, 4655

ZOOM INFORMATION:

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AERI Seminar – Melody Klein

Zoom Only

Title: Formic Acid as a Hydrogen Carrier

Melody Klein:  AERI Seminar (Boncella Group)

Abstract: Hydrogen (H2) is a promising energy carrier that has the potential to decrease the dependence for fossil fuels in the transportation industry. However, there are challenges with the production, storage, and transportation of hydrogen. The traditional methods of gaseous H2 storage and transportation pose significant safety and energy requirement drawbacks. An alternative to traditional storage and transportation methods is a liquid chemical hydrogen carrier, such as formic acid. The use of formic acid requires a selective catalyst that accesses the reversible dehydrogenation decomposition pathway. This is because the dehydrogenation pathway produces H2 and CO2, the former of which is used for fuel production whereas the irreversible dehydration pathway produces H2O and CO, the latter of which poisons the fuel cell catalyst and as well as destroying the liquid hydrogen carrier. This presentation will discuss recent developments of formic acid dehydrogenation catalysis.

NOTE: Please note that the meeting will be locked at 3:10 pm, so all attendees should login in early as they will not be able to view the seminar if they log in after 3:10 pm.

Zoom Information:

Join from PC, Mac, Linux, iOS, or Android: https://wsu.zoom.us/j/92243809836?pwd=VnlONzlncVRhUExIVTV3WURhclJSZz09

Meeting ID: 922 4380 9836
Passcode: 493551
Date & Time: Nov 6, 2020 03:00 PM Pacific Time (US and Canada)
Every week on Fri, until Nov 13, 2020, 2 occurrence(s)
Nov 6, 2020 03:00 PM
Nov 13, 2020 03:00 PM

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Oral Prelim Exam Announcement

Tuesday, November 3rd @ 12:30 pm; ZOOM ONLY

Aaron Hendricksen (Mancini Group)

Title: Multivalent Immunostimulant Glycopolymers as Novel Adjuvants and Immunotherapeutics

 Abstract: The development of rationally designed adjuvants is critical for the efficacy of purified antigens used in modern vaccine formulations including those developed for cancer immunotherapy. Few adjuvants are licensed for use in human vaccines at this time, however recent advances in the understanding of immune activation allow for development of discrete motifs targeting Pattern Recognition Receptors (PRRs) to the desired clinical benefit. Of these PRRs, the Macrophage Inducible C-Type Lectin receptor (MINCLE) has become an attractive target for adjuvant design. Despite this, only one experimental adjuvant CAF01 has been formulated for human use with trehalose dibehenate, a synthetic analogue of the glycolipid responsible for pathogenicity of Mycobacterium tuberculosis, whereby multivalent agonism is exploited for effective signaling. Furthermore, aryl derivatives of trehalose including the natural product brartemicin have demonstrated anti-invasive properties by inhibition of key proteins involved in tumor metathesis, highlighting the promising role of C-type lectin receptor agonists as anti-cancer therapeutics. In this work, we will investigate the molecular parameters for multivalent MINCLE agonism with a trehalose-based glycopolymer scaffold constructed via controlled/living radical polymerization for precise control of agonist density and macromolecular architecture.  In addition, we propose the development of a hydrophilic tri-block polymer scaffold that retains MINCLE-specific immunogenicity and expands the platform to include aryl trehalose subunits for application in cancer immunotherapy. We propose a hydrophilic A-block for improved solubility and passive targeting of tumor tissue, a lipidated trehalose B-block to exploit multivalent MINCLE agonism, and an aryl trehalose C-block for delivery of anti-invasive therapeutics to the tumor microenvironment. The proposed work will elucidate the discrete molecular parameters of multivalent agonism for improvement of adjuvant design and subsequent control of immune response, while combined properties of MINCLE dependent immunogenicity and metathesis inhibition in tandem with the in vivo benefits of macromolecular carriers will serve to broaden their potential in cancer immunotherapy.

 

Zoom info:

Join from PC, Mac, Linux, iOS, or Android: https://wsu.zoom.us/j/98706507281

Meeting ID: 987 0650 7281

Date & Time: Nov 3, 2020 12:30 PM Pacific Time (US and Canada)

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Join from WSU Conference Room System (Polycom)

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  4. Enter the Meeting ID: 987 0650 7281
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Organic Chemistry Proposal Seminar – Aaron Hendricksen

Oral Prelim Exam Announcement

Tuesday, November 3rd @ 12:30 pm; ZOOM ONLY

Aaron Hendricksen (Mancini Group)

Title: Multivalent Immunostimulant Glycopolymers as Novel Adjuvants and Immunotherapeutics

 Abstract: The development of rationally designed adjuvants is critical for the efficacy of purified antigens used in modern vaccine formulations including those developed for cancer immunotherapy. Few adjuvants are licensed for use in human vaccines at this time, however recent advances in the understanding of immune activation allow for development of discrete motifs targeting Pattern Recognition Receptors (PRRs) to the desired clinical benefit. Of these PRRs, the Macrophage Inducible C-Type Lectin receptor (MINCLE) has become an attractive target for adjuvant design. Despite this, only one experimental adjuvant CAF01 has been formulated for human use with trehalose dibehenate, a synthetic analogue of the glycolipid responsible for pathogenicity of Mycobacterium tuberculosis, whereby multivalent agonism is exploited for effective signaling. Furthermore, aryl derivatives of trehalose including the natural product brartemicin have demonstrated anti-invasive properties by inhibition of key proteins involved in tumor metathesis, highlighting the promising role of C-type lectin receptor agonists as anti-cancer therapeutics. In this work, we will investigate the molecular parameters for multivalent MINCLE agonism with a trehalose-based glycopolymer scaffold constructed via controlled/living radical polymerization for precise control of agonist density and macromolecular architecture.  In addition, we propose the development of a hydrophilic tri-block polymer scaffold that retains MINCLE-specific immunogenicity and expands the platform to include aryl trehalose subunits for application in cancer immunotherapy. We propose a hydrophilic A-block for improved solubility and passive targeting of tumor tissue, a lipidated trehalose B-block to exploit multivalent MINCLE agonism, and an aryl trehalose C-block for delivery of anti-invasive therapeutics to the tumor microenvironment. The proposed work will elucidate the discrete molecular parameters of multivalent agonism for improvement of adjuvant design and subsequent control of immune response, while combined properties of MINCLE dependent immunogenicity and metathesis inhibition in tandem with the in vivo benefits of macromolecular carriers will serve to broaden their potential in cancer immunotherapy.

 Zoom info:

Join from PC, Mac, Linux, iOS, or Android: https://wsu.zoom.us/j/98706507281

Meeting ID: 987 0650 7281

Date & Time: Nov 3, 2020 12:30 PM Pacific Time (US and Canada)

Please refer to this guide on Joining WSU Zoom Meetings before trying to join the meeting.

https//confluence.esg.wsu.edu/display/KB/Zoom+-+Joining+Meetings+and+Best+Practices

Note: Zoom Account authentication is required to join this meeting.

Join from WSU Conference Room System (Polycom)

  1. Using the touch panel, or remote control,  select ‘Place a Call’
  2. Enter the IP Address including periods: 162.255.37.11
  3. Press the pound key twice ‘##’
  4. Enter the Meeting ID: 987 0650 7281
  5. Press ‘Call’

Join from Conference Room System with SIP

98706507281@zoomcrc.com

 

Share Screen/Content Wirelessly

Go to https://share.zoom.us and enter Meeting ID: 987 0650 7281

Phone Call (long distance)

+1 253 215 8782

+12532158782,,98706507281# US (One Tap Mobile Call)

Find your international phone number: https://wsu.zoom.us/u/a6eczfcc5

For technical support with WSU conference rooms, contact your local IT team

For support or feature requests, please go to https://its.wsu.edu/wsu-video-conferencing-services/

 

 

Organic Seminar-Emily Savoy (Berkman)

Title: Development of a Urine-Based Liquid Biopsy for Prostate Cancer

Emily Savoy (Berkman Group)

Abstract: A urine-based liquid biopsy is a non-invasive approach to detect validated biomarkers for the evaluation or diagnosis of prostate cancer. Extracellular vesicles (EVs) have received significant attention for their role in cell-cell communication and are currently being explored as a tool for prognostic and diagnostic management. Consequently, various exosome isolation methods, based on different principles, have been developed. The important enzyme biomarker Prostate Specific Membrane Antigen, PSMA, is a validated target for prostate cancer and is also expressed on tumor-derived exosomes. Tumor secreted exosomes could be used as an extracellular resource of PSMA and thus, as a simple and effective non-invasive approach to detect prostate cancer. By using a PSMA inhibitor magnetic isolation system, there is the potential to rapidly capture and quantify progression of prostate cancer. In this presentation, inhibitor synthesis and various exosome isolation methods will be discussed. Future work includes the nondestructive capture and characterization of tumor-derived exosomes through a variety of exosome isolation methods.