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Organic Chemistry Seminar

April 2 @ 12:30 pm - 1:30 pm

Hosog Yoon (Berkman Group)

Design of a Small-Molecule Drug Conjugate for Prostate Cancer Targeted Theranostics

Targeted therapy has become an effective strategy of precision medicine for cancer treatment. Based on the success of antibody-drug conjugates (ADCs), here we report a theranostic design of small-molecule drug conjugates (T-SMDCs) for targeted imaging and chemotherapy of prostate cancer. The structure of T-SMDCs built upon a polyethylene glycol (PEG) scaffold consists of (i) a chelating moiety for positron emission tomography (PET) imaging when labeled with 68Ga, a positron-emitting radioisotope; (ii) a prostate specific membrane antigen (PSMA) specific ligand for prostate cancer targeting; and (iii) a cytotoxic drug (DM1) for chemotherapy. For proof-of-concept, such a T-SMDC, NO3A-DM1-Lys-Urea-Glu, was synthesized and evaluated. The chemical modification of Lys-Urea-Glu for the construction of the conjugate did not compromise its specific binding affinity to PSMA. The PSMA-mediated internalization of 68Ga-labeled NO3A-DM1-Lys-Urea-Glu displayed a time-dependent manner, allowing the desired drug delivery and release within tumor cells. The antiproliferative activity of the TSMDC showed a positive correlation with the PSMA expression level. Small animal PET imaging with 68Ga-labeled NO3ADM1-Lys-Urea-Glu exhibited significantly higher uptake (p < 0.01) in the PSMA positive PC3-PIP tumors (4.30 ± 0.20%ID/g) at 1 h post injection than in the PSMA negative PC3-Flu tumors (1.12 ± 0.42%ID/g). Taken together, we have successfully designed and synthesized a T-SMDC system for prostate cancer targeted imaging and therapy.

Details

Date:
April 2
Time:
12:30 pm - 1:30 pm
Event Categories:
,

Venue

Fulmer 438

Organizer

Dr. Phil Garner
Phone:
509-335-7620
Email:
ppg@wsu.edu
Website:
https://chem.wsu.edu/faculty/phil-garner/