Clinical/Research Assistant Professor
Pullman, WA 99164-4630
Ph.D., Organic Chemistry, 2014
University of California, Los Angeles
Department of Chemistry and Biochemistry
Thesis Advisor: Dr. Miguel A. Garcia-Garibay
B.S., Chemistry and Botany, 2007
Iowa State University, Ames IA
Department of Chemistry
Research Advisors: Dr. Nicola L. Pohl and Dr. Walt Trahanovsky
Dr. Nielsen’s research focus is in synthetic immunology, including the synthesis of smart immunostimulant bioconjugates, and efflux from multidrug- resistant cancers. She additionally provides support in the synthesis and characterization of immunostimulant polymers, management of the Mancini lab, and graduate and undergraduate instruction.
Pulukuri A., Burt, A., Opp LK, McDowell, C., Nielsen, AE, Mancini RJ “Acquired Drug Resistance Enhances Imidazoquinoline Efflux by P-Glycoprotein” –under review
Ryan AT, Pulukuri AJ, Davaritouchaee M, Abassi A, Hendricksen AT, Opp LK, Burt AJ, Nielsen AE, Mancini RJα, “Comparing the Cancer Cell Metabolism and Immunogenicity of Glycosidase-Directed Resiquimod Prodrugs Mediated by Cancer Cell Metabolism”, Acta Pharmacologica Sinica, 2020, 41, 9915-1004.
*Highlighted by Scientia: “Exploiting Drug Metabolism to Activate Immunity Against Cancer”
Zhang CY, Lin W, Gao J, Shi X, Davaritouchaee M, Nielsen AE, Mancini RJ, Wang Z, “pH-Responsive Nanoparticles Targeted to Lungs for Improved Therapy of Acute Lung Inflammation/Injury”, ACS Applied Materials and Interfaces, 2019, 11, 18, 16380
Burt AJ, Hantho JD, Nielsen AE, Mancini, RJ, “An Enzyme-Directed Imidazoquinoline Activated by Drug Resistance” Biochemistry, 2018, 57, 15, 2184-2188
Nielsen AE α, Mancini RJ α, “An Enzyme-Directed Pro-Immunotherapeutic Activated by Muliti-Drug Resistance” Cancer Research, 2018, 78, (Supplement 13), LB-065.
Nielsen AE, Hantho JD, Mancini RJ, “Synthetic Agonists of NOD-Like, RIG-I-Like, and C-Type Lectin Receptors for Probing the Inflammatory Immune Response” Future Medicinal Chemistry, 2017, 9, 12, 1345-1360. –Invited Submission
*Highlighted by Macchiarulo, A. “Immunotherapy… a Pursuit Race to Tomorrow’s Medicines” Future Medicinal Chemistry, 2017, 9, 12, 1297-1299.
Hantho JD, Strayer TA, Nielsen AE, Mancini RJ, “An Enzyme-Directed Imidazoquinoline for Cancer Immunotherapy” ChemMedChem, 2016, 11, 22, 2496-2500.
*Featured on cover of the journal
Mancini RJ, Nielsen AE, Hantho JD, “Toll-Like Receptor Agonists Targeted to Cancer Cell Metabolism” Journal of Immunology, 2016, 196, (1 Supplement), 144.3.
Nielsen, A. E.; Stopin, A. P.; Garcia-Garibay, M. A. “Photo-Induced and Thermal Decarbonylation of Crystalline Biaryl Cyclopropenones with Bulky Substituents: Insights into Solid-to-Solid Transformations with Reactions that Challenge the Topochemical Postulate” manuscript in preparation.
Nielsen, A. E.; Kuzmanich, G. K.; Garcia-Garibay, M. A. “Quantum Chain Reaction of Tethered Diarylcyclopropenones in the Solid State and Their Distance-Dependence in Solution Reveal a Dexter S2-S2 Energy Transfer Mechanism” J. Phys. Chem. A., 2014, 118 (10), pp 1858-1863.
Mancini RJ, Nielsen AE, Ryan AT, Burt AJ, “Bystander-Assisted Immunomodulators Prodrugs and Uses Thereof” United States Provisional Patent Application, WSU OC 20/3335, March 31, 2020.
Mancini, R.J.; Nielsen A.E.; Hantho, J.D. “Enzyme-Directed Pro-Immunostimulant and Uses Thereof” United States Non-Provisional Patent Application, 15/722,018, October 2, 2017.