Garner, Phil

Research

Research in the Garner lab focuses on the development of new enabling chemistries and the synthesis of biologically active molecules. In this context, our intellectual activities may be viewed as architecture (design and construction) on the molecular scale. Chemical synthesis (the discipline associated with building molecular structures) is the common element that underlies all of our research endeavors.

Current research projects include the development of new methodology for the convergent synthesis and site-specific modification of proteins as well as the application of the asymmetric [C+NC+CC] coupling reaction to biologically active pyrrolidine-containing targets.

Visit the Garner Research Group for more research highlights.

Publications

• Xuan, W.; Collins, D.; Koh, M.; Yao, A.; Xiao, H.; Garner, P.; Schultz, P. G., “Site-Specific Incorporation of a Thioester Containing Amino Acid into Proteins” ACS Chem. Biol. 2018, 13, 578-581.
• Joseph, R.; Morales Padilla, M.; Garner, P., “Solid phase synthesis of ω-aspartic thioacid containing peptides” Tetrahedron Lett. 2015, 56, 4302.
• Murray, C.; Dyer, F. B.; Garner, P., “Solid phase synthesis and ligative processing of photocaged aziridine-2-carbonyl-terminated peptides”  Tetrahedron Lett. 2015, 56, 3636. (Special issue for Prof. Harry Wasserman)
  
• Garner, P.; Weerasinghe, L.; Van Houten, I.; Hu, J., “A Concise [C+NC+CC] Coupling-Enabled Synthesis of Kaitocephalin” Chem. Comm. 2014, 50, 4908.
• Joseph, R.; Murray, C.; Garner, P., “Catalytic Asymmetric Exo-Selective [C+NC+CC] Reaction” Org. Lett. 2014, 16, 1550.
• Joseph, R.; Dyer, F. B.; Garner, P., “Rapid Formation of N-Glycopeptides via Cu(II)-Promoted Glycosylative Ligation” Org. Lett. 2013, 15, 732.
• Ahmed, A. H.; Hamada, M.; Shinada, T.; Ohfune, Y.; Weerasinghe, L.; Garner, P. P.; Oswald, R. E., “The Structure of (−)-Kaitocephalin Bound to the Ligand Binding Domain of the (S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA)/Glutamate Receptor, GluA2” J. Biol. Chem. 2012, 287, 41007.
• Garner, P.; Weerasinghe, L.; Youngs, W. J.; Wright, B.; Wilson, D.; Jacobs, D. “[C+NC+CC] Coupling-Enabled Synthesis of Influenza Neuramidase Inhibitor A-315675“ Org. Lett. 2012 14, 1326.
• Dyer, F. B.; Park, C.-M.; Joseph, R.; Garner, P. “Aziridine-Mediated Ligation and Site-Specific Modification of Unprotected Peptides” J. Am. Chem. Soc. 2011, 133, 20033.
• Garner, P.; Kaniskan, H. U.; Keyari, C. M.; Weerasinghe, L. “Asymmetric [C + NC + CC] Coupling Entry to the Naphthyridinomycin Natural Product Family: Formal Total Synthesis of Cyanocycline A and Bioxalomycin β2” J. Org. Chem. 2011, 76, 5283.
• Garner, P.; Kaniskan, H.U. “The Asymmetric [C+NC+CC] Coupling Reaction: Development and Application to Natural Product Synthesis” Curr. Org. Syn. 2010, 7, 348.
• Isleyen, A.; Gonsky, C.; Ronald, R. C.; Garner, P. “Efficacious Preparation of Oppolzer’s Glycylsultam via the Delépine Reaction” Synthesis 2009, 8, 1261.
• Kahsai, A. W.; Cui, J.; Kaniskan, H. Ü.; Garner, P. P.; Fenteany, G. “Analogs of Tetrahydroisoquinoline Natural Products that Inhibit Cell Migration and Target Galectin-3 Outside of Its Carbohydrate- Binding Site” J. Biol. Chem. 2008, 283, 24534.
• H. Ümit Kaniskan and Philip Garner “An Efficient Synthetic Approach to Cyanocycline A and Bioxalomycin b2 via [C+NC+CC] Coupling” J. Am. Chem. Soc. 2007, 129, 15460.
• Garner, P.; Hu, J.; Parker, C. J.; Youngs, W. J.; Medvetz, D. “The CuI Catalyzed Exo-Selective Asymmetric Multicomponent [C+NC+CC] Reaction” Tetrahedron Lett. 2007, 48, 3867.
• Dogan, O.; Koyuncu, H.; Garner, P.; Bulut, A.; Youngs, W. J.; Panzner, M. “New Zinc(II)-Based Catalyst for Asymmetric Azomethine Ylide Cycloaddition Reactions” Org. Lett. 2006, 8, 4687.