Pullman, WA 99164-4630
Post-Doctoral Research Associate, Aerosol Mass Spectrometry, 1995-1998
Oak Ridge National Laboratory, J.M. Ramsey
Post Doctoral Research Associate, Biological Mass Spectrometry, 1992-1994
Indiana University, J.P. Reilly
Ph.D. Physical Chemistry, 1992
University of Illinois at Chicago, IL
M.S. Physical Chemistry, 1984
University of Texas, Austin, TX
B.S. Chemistry, 1981
University of Delaware, Newark, DE
Feb. 1998 to 2010: Staff Scientist, Oak Ridge National Laboratory. Research has involved: characterization of aerosols by mass spectrometry; development of aerosol-base MALDI of biomolecules in an ion trap; mass spectrometry of bacteria, chemical weapons agents, explosives; isotope mass spectral analysis of single airborne particles; analysis of the formation of elemental carbon by hydrocarbon pyrolysis, formation of carbon nanotubes and carbon composites; digital ion trap development; development of miniature ion trap mass spectrometers; development of methods and instrumentation to extend the working range of mass spectrometry out to the billion Da range and beyond.
July 2010 to present: Associate professor of chemistry, Washington State University. My group has increased the working range of mass spectrometers from roughly m/z 20,000 to m/z 1,000,000. My research is therefore focused on the development and applications of ultra high mass spectrometry. Application development will focus on the measurement of complex protein distributions, discovery of biomarkers, the interaction of proteins to form complexes with small and large molecules, DNA sequencing and much more. My group will also continue to develop digital waveform technology in the small and large molecule regimes.
1. Brabeck, G.F. and P.T.A. Reilly, Mapping ion stability in digitally driven ion traps and guides. International Journal of Mass Spectrometry, 2014. 364(0): p. 1-8.
2. Brabeck, G.F., et al., The Development of MSn in Digitally-Operated Linear Ion Guides. Analytical Chemistry, 2014. submitted.
3. Singh, R., V. Jayaram, and P.T.A. Reilly, Duty Cycle-Based Isolation in Linear Quadrupole Ion Traps. International Journal of Mass Spectrometry, 2013. 343-344: p. 45-49.
4. Wang, X., et al., Increasing the Trapping Mass Range to m/z = 109—A Major Step Toward High Resolution Mass Analysis of Intact RNA, DNA and Viruses. International Journal of Mass Spectrometry, 2012. 328-329: p. 28-35.
5. Saito, K., et al., A hybrid approach to calculating Coulombic interactions: An effective and efficient method for optimization of simulations of many ions in quadrupole ion storage device with SIMION. International Journal of Mass Spectrometry, 2012. 315: p. 74-80.
6. Liu, T., et al., Targeting prostate cancer cells with a multivalent PSMA inhibitor-guided streptavidin conjugate. Bioorganic and Medicinal Chemistry Letters, 2012. 22(12): p. 3931-3934.
7. Chen, H.J., J. Lee, and P.T.A. Reilly, High-resolution ultra-high mass spectrometry: Increasing the m/z range of protein analysis. Proteomics, 2012. 12(19-20): p. 3020-3029.
8. Lee, J. and P.T.A. Reilly, Limitation of Time-of-Flight Resolution in the Ultra High Mass Range. Analytical Chemistry, 2011. 83(15): p. 5831-5833.
9. Lee, J., et al., Simulation of duty cycle-based trapping and ejection of massive ions using linear digital quadrupoles: The enabling technology for high resolution time-of-flight mass spectrometry in the ultra high mass range. International Journal of Mass Spectrometry 2011. 304(1): p. 36-40.
10. Lee, J., et al., High Resolution Time-of-Flight Mass Analysis of the Entire Range of Intact Singly-Charged Proteins. Analytical Chemistry, 2011. 83: p. 9406-9412.
11. Koizumi, H., W.B. Whitten, and P.T.A. Reilly, Controlling the Expansion into Vacuum—the Enabling Technology for Trapping Atmosphere-Sampled Particulate Ions Journal of the American Society for Mass Spectrometry, 2010. 21(1): p. 242-248.
12. Koizumi, H., et al., A novel phase-coherent programmable clock for high-precision arbitrary waveform generation applied to digital ion trap mass spectrometry. International Journal of Mass Spectrometry, 2010. 292(1-3): p. 23-31.
13. Koizumi, H., et al., Derivation of mathematical expressions to define resonant ejection from square and sinusoidal wave ion traps. International Journal of Mass Spectrometry 2009. 286(2-3): p. 64-69.
14. Koizumi, H., et al., The Effect of Endcap Electrode Holes on the Resonant Ejection from an Ion Trap. International Journal of Mass Spectrometry, 2008. 281(3): p. 108-114.
15. Koizumi, H., W.B. Whitten, and P.T.A. Reilly, Trapping of Intact, Singly-Charged, Bovine Serum Albumin Ions Injected from the Atmosphere with a 10-cm Diameter, Frequency-Adjusted, Linear Quadrupole Ion Trap. Journal of the American Society for Mass Spectrometry, 2008. 19(12): p. 1942-1947.
16. Harris, W.A., P.T.A. Reilly, and W.B. Whitten, Detection of chemical warfare-related species on complex aerosol particles deposited on surfaces using an ion trap-based aerosol mass spectrometer. Analytical Chemistry, 2007. 79(6): p. 2354-2358.
17. Harris, W.A., P.T.A. Reilly, and W.B. Whitten, Aerosol MALDI of peptides and proteins in an ion trap mass spectrometer: Trapping, resolution and signal-to-noise. International Journal of Mass Spectrometry, 2006. 258(1-3): p. 113-119.
18. Harris, W.A., et al., Transportable Real-Time Single-Particle Ion Trap Mass Spectrometer Review Scientific Instruments, 2005. 76(6): p. 8.
19. Harris, W.A., P.T.A. Reilly, and W.B. Whitten, MALDI of individual biomolecule-containing airborne particles in an ion trap mass spectrometer. Anal. Chem., 2005. 77(13): p. 4042-4050.
20. Whitten, W.B., P.T.A. Reilly, and J.M. Ramsey, High-pressure ion trap mass spectrometry. 2004. 18(15): p. 1749-1752.