Pullman, WA 99164-4630
Post-Doctoral Research Associate, Aerosol Mass Spectrometry, 1995-1998
Oak Ridge National Laboratory, J.M. Ramsey
Post Doctoral Research Associate, Biological Mass Spectrometry, 1992-1994
Indiana University, J.P. Reilly
Ph.D. Physical Chemistry, 1992
University of Illinois at Chicago, IL
M.S. Physical Chemistry, 1984
University of Texas, Austin, TX
B.S. Chemistry, 1981
University of Delaware, Newark, DE
Feb. 1998 to 2010: Staff Scientist, Oak Ridge National Laboratory. Research has involved: characterization of aerosols by mass spectrometry; development of aerosol-base MALDI of biomolecules in an ion trap; mass spectrometry of bacteria, chemical weapons agents, explosives; isotope mass spectral analysis of single airborne particles; analysis of the formation of elemental carbon by hydrocarbon pyrolysis, formation of carbon nanotubes and carbon composites; digital ion trap development; development of miniature ion trap mass spectrometers; development of methods and instrumentation to extend the working range of mass spectrometry out to the billion Da range and beyond.
July 2010 to present: Associate professor of chemistry, Washington State University. My group has increased the working range of mass spectrometers from roughly m/z 20,000 to m/z 1,000,000. My research is therefore focused on the development and applications of ultra high mass spectrometry. Application development will focus on the measurement of complex protein distributions, discovery of biomarkers, the interaction of proteins to form complexes with small and large molecules, DNA sequencing and much more. My group will also continue to develop digital waveform technology in the small and large molecule regimes.
- Opačić, B., A.P. Huntley, B.H. Clowers, and P.T.A. Reilly, Digital Mass Filter Analysis in Stability Zones A and B. Journal of Mass Spectrometry, 53: p. 1155-1168. , 2018 https://doi.org/10.1002/jms.4295.
- Opačić, B., N.M. Hoffman, Z.P. Gotlib, B.H. Clowers, and P.T.A. Reilly, Using Digital Waveforms to Mitigate Solvent Clustering During Mass Filter Analysis of Proteins. Journal of The American Society for Mass Spectrometry, 29(10): p. 2081-2085, 2018.
- Opačić, B., N.M. Hoffman, B.H. Clowers, and P.T.A. Reilly, Impact of injection potential on measured ion response for digitally driven mass filters. International Journal of Mass Spectrometry, 434: p. 1-6, 2018.
- Hoffman, N.M., Z.P. Gotlib, B. Opačić, A.P. Huntley, A.M. Moon, K.E.G. Donahoe, G.F. Brabeck, and P.T.A. Reilly, Digital Waveform Technology and the Next Generation of Mass Spectrometers. Journal of The American Society for Mass Spectrometry, 29: p. 331-341, 2018.
- Hoffman, N.M., Z.P. Gotlib, B. Opačić, B.H. Clowers, and P.T.A. Reilly, A comparison based digital waveform generator for high resolution duty cycle. Review of Scientific Instruments, 89(8): p. 084101, 2018.
- Hoffman, N.M., B. Opacic, and P.T.A. Reilly, An Inexpensive Square Waveform Ion Funnel Driver. Review of Scientific Instruments, 88(1): p. 3, 2017.
- Hoffman, N.M., Z.P. Gotlib, B. Opačić, B.H. Clowers, and P.T.A. Reilly. Generation of Digital Waveforms with High Resolution Duty Cycle in 65th American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics. 2017. Indianapolis, IN.
- Opačić, B., L. Wang, N.M. Hoffman, Z.P. Gotlib, B.H. Clowers, and P.T.A. Reilly. Digitally-Driven Ion Funnels to Enhance High Mass Ion Collection. in The American Society for Mass Spectrometry 64th conference on Mass Spectrometry and Applied Topics. 2016. San Antonio, TX.
- Brabeck, G.F. and P.T.A. Reilly, Computational analysis of non-traditional waveform quadrupole mass filters Journal of The American Society for Mass Spectrometry, 27(6): p. 1122-1127, 2016.
- Brabeck, G.F., H. Koizumi, E. Koizumi, and P.T.A. Reilly, Characterization of quadrupole mass filters operated with frequency-asymmetric and amplitude-asymmetric waveforms. International Journal of Mass Spectrometry, 404: p. 8-13, 2016.
- Brabeck, G.F. and P.T.A. Reilly, Ion Manipulation by Digital Waveform Technology, in LCGC North America. 2015. p. 34-44.
- Brabeck, G.F. and P.T.A. Reilly, Mapping ion stability in digitally driven ion traps and guides. International Journal of Mass Spectrometry, 364: p. 1-8, 2014.
- Brabeck, G.F., H. Chen, N.M. Hoffman, L. Wang, and P.T.A. Reilly, Development of MSn in Digitally Operated Linear Ion Guides. Analytical Chemistry, 86(15): p. 7757-7763, 2014.
- Wang, X., H. Chen, J. Lee, and P.T.A. Reilly, Increasing the trapping mass range to m/z=10(9)-A major step toward high resolution mass analysis of intact RNA, DNA and viruses. International Journal of Mass Spectrometry, 328: p. 28-35, 2012.
- Saito, K., P.T.A. Reilly, E. Koizumi, and H. Koizumi, A hybrid approach to calculating Coulombic interactions: An effective and efficient method for optimization of simulations of many ions in quadrupole ion storage device with SIMION. International Journal of Mass Spectrometry, 315: p. 74-80, 2012.
- Reilly, P.T.A., H. Chen, X. Wang, and K.G.E. Donahoe, High resolution TOF-MS of intact singly charged proteins and complexes up to m/z=1,000,000. Abstracts of Papers of the American Chemical Society, 244, 2012.
- Liu, T., J.R. Nedrow-Byers, M.R. Hopkins, L.Y. Wu, J. Lee, P.T.A. Reilly, and C.E. Berkman, Targeting prostate cancer cells with a multivalent PSMA inhibitor-guided streptavidin conjugate. Bioorganic & Medicinal Chemistry Letters, 22(12): p. 3931-3934, 2012.
- Chen, H., J. Lee, and P.T.A. Reilly, High-resolution ultra-high mass spectrometry: Increasing the m/z range of protein analysis. Proteomics, 12(19-20): p. 3020-3029, 2012.
- Lee, J. and P.T.A. Reilly, Limitation of Time-of-Flight Resolution in the Ultra High Mass Range. Analytical Chemistry, 83(15): p. 5831-5833, 2011.
- Lee, J., H. Chen, T. Liu, C.E. Berkman, and P.T.A. Reilly, High Resolution Time-of-Flight Mass Analysis of the Entire Range of Intact Singly-Charged Proteins. Analytical Chemistry, 83: p. 9406-9412, 2011.
- Reilly, P.T. and H. Koizumi, Agile high resolution arbitrary waveform generator with jitterless frequency stepping, U.S. Patent, Editor. 2010 UT-Battelle, LLC (Oak Ridge, TN): United States.
- Koizumi, H., W.B. Whitten, and P.T.A. Reilly, Controlling the Expansion into Vacuum—the Enabling Technology for Trapping Atmosphere-Sampled Particulate Ions Journal of the American Society for Mass Spectrometry, 21(1): p. 242-248, 2010.