James Hurst

  1. Professor Emeritus
Email Addresshurst@wsu.edu

Biography

Education

  • Post-Doctoral Study, 1966-1969
    Cornell  University
  • Ph.D. Physical Inorganic Chemistry, 1966
    Stanford University
  • B.A. Chemistry, 1962
    Cornell College

Research

Professor Hurst received his PhD degree at Stanford under the direction of the Nobel laureate Henry Taube.  Following three additional years study as a National Institutes of Health Postdoctoral Fellow with Gordon Hammes at Cornell University, he joined the faculty at the Oregon Graduate Institute for Science and Technology.  In 1993, he became a member of the chemistry faculty at Washington State University.  He has also held positions as Invited Professor at the Ecole Polytechnique Federalé de Lausanne in Switzerland and Université Louis Pasteur in Strasbourg, France, and since retiring, has also been a visiting scientist within the Department of Biochemistry & Biophysics at Oregon State University in Corvallis, OR.  Broadly, his research has been involved with characterizing the oxidative chemistry of living cells and in mimicking essential cellular functions using simpler organized chemical systems.  Major long-term projects have included developing multinuclear inorganic catalysts for water oxidation as models for biological oxygen-evolving complexes, developing self-assembling biomimetic systems for photogeneration of fuels, and identifying cellular oxidants produced during host resistance to disease and their microbicidal mechanisms.  This last topic has recently been expanded through collaborative research at Oregon State to include mechanisms by which oxidative stress can lead to diseased states in host organisms.  Recent publications are listed below.

References

  • A. Stull, R. D. Britt, J. L. McHale, F. J. Knorr, S. V. Lymar, J. K. Hurst, “Anomalous Reactivity of Ceric Nitrate in Ruthenium ‘Blue Dimer’ Catalyzed Water Oxidation” J. Am. Chem. Soc. 134, 19973-19976 (2012).
  • K. Hurst “What really happens in the neutrophil phagosome?” Free Radic. Biol. Med. 53, 508-520 (2012).
  • A. Stull, T. A. Stich, J. K. Hurst, R. D. Britt, “EPR Analysis of a Transient Species Formed During Water Oxidation Catalyzed by the Complex Ion [(bpy)2Ru(OH2)]2O4+” Inorg. Chem. 52, 4578-4586 (2013).
  • E. Polansky, J. K. Hurst, S. V. Lymar, “Application of Pulse Radiolysis to Mechanistic Investigations of Water Oxidation Catalysis” Eur. J. Inorg. Chem. 618-634 (2014).
  • D. Roemeling, J. Williams, J. S. Beckman, J. K. Hurst, “Imidazole Catalyzes Chlorination by Unreactive Primary Chloramines” Free Radic. Biol. Med. 82, 167-178 (2015).
  • K. Hurst, M. D. Roemeling, S. V. Lymar, “Mechanistic Insight into Peroxydisulfate Reactivity: Oxidation of the cis,cis-[Ru(bpy)2(OH2)]2O4+ ‘Blue Dimer’ “ J. Phys. Chem. B 119, 7749-7760 (2015).
  • J. Sirois, L. Padgitt-Cobb, M. A. Gallegos, J. S. Beckmann, C. M. Beaudry, J. K. Hurst, “Oxidative Release of Copper from Pharmacologic Cupric bis-Thiosemicarbazone Compounds” Inorg. Chem. 57, 8923-8932, (2018).
  • Augusto, S. Goldstein, J. K. Hurst, J. Lind, S. Lymar, G. Merenyi, R. Radi, “Carbon Dioxide-catalyzed Peroxynirite Reactivity.  The Resilience of the Radical Mechanism after Two Decades of Research.” Free Radic. Biol. Med. 135, 210-219 (2019).